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In another study, DCA administration rescued locomotor deficits and elevated PDH activity in mice with ME/CFS-like manifestations induced by a 25-day repeated forced swimming test [145]

Biol Chem 395(2):203230 Makrecka M, Kuka J, Volska K, Antone U, Sevostjanovs E, Cirule H, Grinberga S, Pugovics O, Dambrova M, Liepinsh E (2014) Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria

In summary, our study uncovered a novel role of adipocyte-expressed SIRT3 in mitigating infiltration and pro-inflammatory polarization of macrophages, thereby attenuating AT inflammation and protecting against obesity-related insulin resistance